November 27th 2025.
On November 24th, President Donald J. Trump took action by signing a sweeping Executive Order to establish the "Genesis Mission." This will be a coordinated national initiative that aims to secure global technological supremacy by utilizing artificial intelligence in scientific discovery. The President has declared this to be a historic and urgent effort, similar to the Manhattan Project, which will utilize years of federal scientific investment to tackle the most challenging issues of the 21st century.
The Department of Energy has been designated as the lead agency for this mission, with the Secretary of Energy being tasked with creating and operating the American Science and Security Platform. This platform will serve as a secure and integrated infrastructure for harnessing the vast collection of federal scientific datasets. The main goal of the Genesis Mission is to develop scientific foundation models and AI agents that can accelerate breakthroughs in critical national domains, such as advanced manufacturing, biotechnology, and energy.
President Trump believes that this mission will not only strengthen national security but also secure energy dominance, enhance workforce productivity, and provide a high return on taxpayer investment for research and development. To ensure the success of this initiative, the DOE Secretary is required to integrate resources from various federal agencies, including national laboratory supercomputers and secure cloud-based computing environments, into the unified Platform.
Collaboration with external entities that possess advanced AI capabilities is also a crucial aspect of this mission. The Secretary is directed to establish formal mechanisms for working with these entities, including standardized partnership frameworks and clear policies for the commercialization of any intellectual property developed under the Genesis Mission. One of the biggest challenges of this mission will be data integration. Within 120 days, the Secretary must identify initial data assets and develop a plan for securely incorporating datasets from federally funded research, academia, and approved private-sector partners.
To ensure broad engagement, the Executive Order emphasizes the need for collaboration and mandates the Assistant to the President for Science and Technology to provide general leadership and coordination through the National Science and Technology Council. To encourage national involvement, the APST and the Secretary are required to establish competitive programs for research fellowships, internships, and apprenticeships focused on AI-enabled science, with placements at DOE national laboratories to provide hands-on training and access to the Platform.
The Executive Order highlights the importance of the Manhattan Project in conveying the urgency, national scope, and ambition of the Genesis Mission. The Manhattan Project was a top-secret research and development program during World War II, aimed at developing the first atomic weapons. It was a massive effort that involved nearly 130,000 people and cost approximately $2.2 billion. The project successfully produced the atomic bombs dropped on Japan in 1945, bringing an end to the war and ushering in the nuclear age. It also served as the model for American "big science" achievements in the following decades.
The Genesis Mission has an aggressive timeline, with the DOE being required to demonstrate an initial operating capability of the Platform for at least one of the identified national science and technology challenges within 270 days. This is subject to available appropriations. With this Executive Order, President Trump is taking a significant step towards securing America's dominance in technology and advancing scientific discovery for the benefit of the nation.
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